Penn Medicine News Blog Archive: Translational Research

Repairing Injured Kidneys Through Regeneration

By Karen Kreeger | January 15, 2016 | Comments Kidney

The capacity to regenerate has mythic qualities for most of us, but the human body has very little ability to regrow body parts on its own compared to say, flatworms that can regenerate a whole new self from small pieces, or some reptiles and amphibians that can regrow lost tails... Read more

What’s the Big Idea? Cancer Leaders to Talk Precision Medicine

By Steve Graff | January 6, 2016 | Comments Lab

In a few weeks, top minds in the city and state will gather to discuss one of the hottest cancer topics in healthcare: precision medicine. It’s a term many have heard, seen on a billboard, or even experienced, but what does the omnipresent buzzword really mean today—and for tomorrow? For... Read more

Copper: A ‘Novel Vulnerability’ in Fighting Cancer

By Karen Kreeger | December 16, 2015 | Comments Copper

I looked at the ornaments on the desk. Everything standard and all copper. A copper lamp, pen set and pencil tray, a glass and copper ashtray with a copper elephant on the rim, a copper letter opener, a copper thermos bottle on a copper tray, copper corners on the blotter... Read more

The Family and Lab Behind a ‘Precious’ Donation to Basic Research

By Karen Kreeger | November 20, 2015 | Comments image from http://s3.amazonaws.com/hires.aviary.com/k/mr6i2hifk4wxt1dp/15112017/8640e83a-ae21-4b3c-83ea-6dca3b0c3d42.png

In 2009, Sarah Gray found out during a routine ultrasound that one of the twins she was carrying had anencephaly, a fatal genetic condition where the brain and skull don't fully develop. After his death, she and her husband donated Thomas’s organs and tissues and since then, have been tracking how they've been used. Read more

Looking to Ancient Symbionts for New Cancer Therapies

By Karen Kreeger | October 26, 2015 | Comments Mitochondria Courtesy NICHD

Talk about a eureka moment: Andrea Facciabene, PhD, a research assistant professor of Obstetrics and Gynecology, was taking a walk one day on the Penn campus when it hit him: What do we really need to make immunotherapy a reality for everybody? The answer, he thought, was in the mitochondria,... Read more

Translation Starts at the Bench for Penn Fellow (VIDEO)

By Karen Kreeger | October 19, 2015 | Comments Pipette Fume Hood PP 2015

For postdoctoral fellow Kristen Pauken, PhD, what “gets her up in the morning” are the cancer immunology experiments she is conducting alongside her mentor John Wherry, PhD, director of the Institute for Immunology at the Perelman School of Medicine. His lab concentrates on getting a better handle on what makes... Read more

How Entropy Affects Drug Design

By Karen Kreeger | September 30, 2015 | Comments Dutton Entropic Boltzman_PLD_crop

Entropic Botzmann by Les Dutton, PhD How could entropy, the basis of the second law of thermodynamics -- or simply put, the measure of disorder in a system -- have anything to do with medicine, a seemingly orderly discipline? Ask Kim Sharp, PhD, an associate professor of Biochemistry and Biophysics,... Read more

Using Summertime for a Head Start in the Lab

By Karen Kreeger | August 5, 2015 | Comments Summer in the lab pic Aug 2015

Back in 2013, the Penn Medicine News Blog covered then rising high school junior Kareema Dixon, who started her science career, in part, by participating in the BioEYES program developed by Jamie Shuda, EdD, director of Life Science Outreach at the Institute for Regenerative Medicine (IRM). Dixon continued with her... Read more

What's Eating the Erythrocytes?

By Karen Kreeger | July 8, 2015 | Comments Red Blood Cell Andrew Mason

In the rare, life-threatening disease called paroxysmal nocturnal hemoglobinuria (PNH), patients are stricken with chronic anemia and blood clots, when the oldest part of the immune system -- known as complement -- turns against its own red blood cells, or erythrocytes. Complement is a network of more than 50 proteins... Read more

A “Hardy Perennial” View of Conflict of Interest

By Karen Kreeger | June 12, 2015 | Comments Conflict of interest E Pluribus

Perennials and hope spring eternal. And so it seems does the debate over conflict of interest in academia. The latest deliberations took place last week in the pages of two of the world’s most prestigious medical journals. Three former New England Journal of Medicine (NEJM) editors commented in a British... Read more

New Research on Fungus Aims to Help Asthma Sufferers

By Lee-Ann Donegan | May 13, 2015 | Comments

“Asthma is a chronic disease without a cure,” said Reynold Panettieri, MD, the Robert L. Mayock and David A. Cooper Professor of Medicine in the Pulmonary, Allergy and Critical Care division and chief of the Asthma Section in Penn’s Perelman School of Medicine. But new fungal research from him and... Read more

The New Avengers: Lab-Coated Heroes Honored for Behind-the-Scenes Contributions

By Karen Kreeger | May 5, 2015 | Comments Lab week 2015 logo

Late last month Penn Medicine observed the fortieth Medical Laboratory Professionals Week, a time to recognize the hard work and dedication of the 600-plus lab professionals in more than 30 laboratories across the health system. Read more

What’s Going on Inside the Richards Medical Research Building These Days?

By Karen Kreeger | March 4, 2015 | Comments Richards_Labs_Penn

The early 1960s were a heady time on the medical school campus and another wonderful chapter in its past 250 years. In 1960, Peter Nowell and David Hungerford discovered the Philadelphia chromosome, which linked cancer to genetic abnormalities for the first time. In 1962, Aaron Beck devised a revolutionary form of psychotherapy called cognitive behavioral therapy. Both of these achievements were destined for international fame and utility. In between those clinical accomplishments, in 1961, an eight-story medical research building, designed by iconoclast architect Louis Kahn, was completed on Hamilton Walk. It was named after renowned Penn pharmacologist and department chair Alfred Newton Richards. Read more

Beyond Cancer: When Both Parents Hold BRCA, a New Risk Can Emerge

By Karen Kreeger | January 14, 2015 | Comments Greenberg Cancer Discovery blog post image

Greenberg Cancer Discovery blog post imageMany families are acutely aware that BRCA1 and BRCA2 are the most important breast and ovarian cancer susceptibility genes. But recently a team including researchers at Penn Medicine discovered another risk it can pose in cancer patients when both parents carry the mutation. Read more

Year in Review: A Look Back at 2014!

By Steve Graff | December 31, 2014 | Comments

Before we ring in the New Year, the Penn Medicine department of Communications is taking a look back at 2014, a year filled with more breakthroughs in medical research, growth at the Penn Medicine campus, and philanthropic support. This year, we took a different approach and put together a year...

Cell-adelphia?

By Karen Kreeger | December 4, 2014 | Comments ASCB Larger Than Life Gallery hall between Terminals E-F installation view

A preview of Penn Medicine cell biologists’ activities -- from art to advocacy to abstracts -- at the 2014 American Society for Cell Biology Annual Meeting in Philadelphia this week. Read more

Geroscience? Much More Than a Reaction to the “Silver Tsunami”

By Karen Kreeger | November 25, 2014 | Comments Geroscience The Seven Pillars of Aging

Geroscience is essentially an interdisciplinary field at the crossroads of aging and age-related diseases. Read more

Roundabout RNA: How Circular RNAs Form

By Karen Kreeger | October 24, 2014 | Comments Wilusz Genes Dev blog post pic from Science. jpg

Penn scientists are at the forefront of exploring and pushing back the boundaries of the bewilderingly complex world of RNA.And, Jeremy Wilusz, PhD, a new faculty member in the department of Biochemistry & Biophysics, is adding to that knowledge with a recently published paper in Genes & Development on circular RNAs. Read more

Whole Genome Sequencing of Amish Families Reveals Complexity of Bipolar Disorder

By Karen Kreeger | September 16, 2014 | Comments Lonestar

Perelman School genetics professor Maja Bucan, PhD, told me of her deep appreciation for the work going on at the clinic: “From my first visit to the clinic [Clinic for Special Children], I knew I wanted to be part of their team as a collaborator.” Read more

Liver Regeneration Revealed: Hepatocytes Beget Hepatocytes

By Karen Kreeger | September 11, 2014 | Comments Prometheus Karl-Ludwig Poggemann Flickr

The regenerating liver is center stage in a modern story about how science similarly reinvents and readjusts itself, with a paper out in an early September issue of Cell Stem Cell from the lab of Ben Stanger. Read more

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