Penn Medicine News Blog Archive: Immunology

Transcription Factors Key to Using T Cells Against Cancer, Chronic Infection

Wherry BATF spiral blog post Mar 14
Business is brisk in the lab of John Wherry and his team from the Department of Microbiology and the Institute for Immunology for papers on killer and helper T cells. Two studies -- bound by their focus on transcription factors important in the immune response – have come out of the lab in the last few weeks. And, they both identify potential new targets for cancer immunotherapies.

The “Other”Circulatory System

Kahn JCI image graphic Jan 14
Blood is the life force of animals. But behind the more well-known system of veins, arteries, and capillaries functions the mop-up crew, the vascular network called the lymph system.

The Med Days of Summer

On the Penn Med campus, mid-August marks the start of the end for many undergrads and high-school students who are wrapping up lab experiments and making presentations about their work in an array of programs designed to showcase what research is all about.

Celebrating the Work of Medical Laboratory Professionals

Lab Week 2013 Poster Winner
To show its gratitude to all laboratory professionals, the department of Pathology and Laboratory Medicine celebrated Medical Laboratory Professionals Week April 22-26, with a host of activities, such as Phillies Night, in appreciation of all the hard work and dedication of the hundreds of staff and faculty members working in more than 30 different laboratories across the Penn campus.

Penn Student Policy Group Takes Impactful, Concise Message to DC

Back in December, when the chatter about budget cuts to the National Institutes of Health started getting louder, Penn PhD students Michael Allegrezza and Shaun O’Brien decided it was time to join the conversation and advocate. They wanted to bring that on-the-ground scientist voice into the mix but knew it...

Defining the Traits of Transmitted HIV-1 to Make Better Vaccines

HIV Red Ribbon by Trygve.u Mar 13
Knowing the traits of HIV-1 strains capable of establishing new infections could be important for AIDS vaccine development.

So You Think You’re Exhausted? War-Weary T Cells Have Us All Beat

Wherry Immunity image Dec 12
This time of year has me pretty run down, with birthdays, holidays, concerts, you name it -- all manner of good and bad stress that weighs on one’s immune system. But I never knew my T cells could get exhausted, too. Two papers from the lab of E. John Wherry,...

Lowering the Age of Scientific Independence

Sonnenberg horizontal lab 3 Sept 12
Greg Sonnenberg, PhD, research associate in the Division of Gastroenterology and the Institute for Immunology, is one of 14 early-career scientists supported this year with an NIH Director's Early Independence Award. These support exceptional early-career scientists to move directly into independent research positions by essentially omitting the traditional post-doctoral training period.

Deadly Choices: A Penn virologist takes on the anti-vaccine movement

Exhibit A: This year’s incoming class of the Perelman School of Medicine at the University of Pennsylvania was assigned to read Deadly Choices: How the Anti-Vaccine Movement Threatens Us All, by Paul A. Offit, MD. Issued by Basic Books in 2011, the book came out this year in paperback. During...

It’s a Matter of Presentation

Marks Immunity blog post graph abstract AP3
A research article in a recent issue of Immunity from the lab of Mickey Marks, PhD, professor of Pathology and Laboratory Medicine, in part explains the recurrent bacterial infections in patients with a rare genetic disease called Hermansky-Pudlak Syndrome type 2.

Sepsis: Deceptive and Deadly

Sepsis researcher David Gaieski, MD, an assistant professor of Emergency Medicine in the Perelman School of Medicine and clinical director in Penn’s Center for Resuscitation Science, spoke this week with several news outlets about the issues raised by the case of the 12-year-old New York City boy who died of sepsis after his infection apparently went undetected at his doctor and an emergency room. explored the reasons why these infections can be so difficult to identify when they’re easiest to treat:

Redirecting T Cells to Fight Cancer

June Immunocore cell image Oct 10
Penn Medicine is building a war chest of approaches to enhance the ability of T cells to attack as many cancer types as possible.

Helping Mothers Give Their Babies the Best Start in Life

All of Society Needs to Support Breastfeeding for Everyone to Reap the Maximum Benefits Medical journals, magazines, websites… they’re all touting the same message, something nature has known all along: breastfeeding is beneficial for both babies and mothers. The message is getting through - but not always to everyone who...

Penn Medicine Team Investigates Novel Immunotherapy Techniques for High Grade (Grade IV) Brain Tumors

Neuro-oncologist researchers at Penn are investigating ways to help patients diagnosed with the most aggressive type of brain tumor, Glioblastoma Multiforme. Building on the Abramson Cancer Center's previous success with research designed to attempt to treat cancers using novel immunotherapies, and Penn's neuro-oncology expertise, researchers will be studying two different...

What’s Happening the Rest of the Week at the Philadelphia Science Festival?

The Philadelphia Science Festival Carnival tents have all been folded and hauled away. There have already been four nights of non-stop science cafes at local watering holes. But, there are still six more days of the festival to go, and Penn Medicine faculty will be participating at events on most of those days.

A Medical Translation Long in the Making: From a Millennia-Old Mutation to New Hope for Treating AIDS

A genetic mistake that arose thousands of years ago spares rare HIV-infected individuals the ravages of AIDS. Researchers at Penn’s School of Medicine are in the midst of translating the language of ancient genetic mistakes into today’s cures.

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