Penn scientists are at the forefront of exploring and pushing back the boundaries of the bewilderingly complex world of RNA.And, Jeremy Wilusz, PhD, a new faculty member in the department of Biochemistry & Biophysics, is adding to that knowledge with a recently published paper in Genes & Development on circular RNAs. Read more
Rotenone exposure is also associated with Parkinson’s disease (PD) in humans, but the exact mechanism is unknown. In fact, rotenone is used to induce a rodent model of PD. Mitochondrial abnormalities have been well documented in PD patients, often coinciding with elevated markers of oxidative stress. Despite this evidence, not much is known about how nerve cells die because of the stress. Read more
Perelman School genetics professor Maja Bucan, PhD, told me of her deep appreciation for the work going on at the clinic: “From my first visit to the clinic [Clinic for Special Children], I knew I wanted to be part of their team as a collaborator.” Read more
The regenerating liver is center stage in a modern story about how science similarly reinvents and readjusts itself, with a paper out in an early September issue of Cell Stem Cell from the lab of Ben Stanger. Read more
David Artis, PhD, professor of Microbiology and his team, including first author Lisa Osborne, PhD, demonstrated that mice already infected with parasitic helminths were worse at fighting viral infection. Read more
Every summer, the news is filled with profiles of summer student programs, and those that are aimed at increased participation by minority students in STEM are no exception. The Summer Undergraduate Internship Program at Penn Medicine is one such program. Read more
The winners of the Penn Medicine 2014 “Art in Science" can certainly make pretty pictures with fancy microscopes, but there is also a rich story of scientific inquiry behind each. Read more
WHYY’s Radio Times’ show last Friday focused on much of the progress that’s been made in the world of HIV/AIDS research and care, but there was one terrible set back that had to be addressed. Earlier that morning, news broke that the Malaysia Airlines plane struck down over the Ukraine... Read more
A new study is shedding light on how cells respond to surrounding “stiff” tissue that can influence cells to go rogue—and ultimately cause disease. A better understanding of that process could help advance the development of treatments for cancers and cardiovascular disease resistant to therapy. An article in Science Signaling... Read more
Like many people, I have gone through life without paying much attention to my gut –- except, that is, for the times my stomach gave unmistakable indications that it was upset. Most of the time, what was happening inside said stomach remained unknown. On the whole, it was out of... Read more
The lab of Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology, and colleagues, recently showed in a Cancer Cell study that some tumor components, particularly fibroblasts, constrain tumor growth. Read more
As the Perelman School of Medicine fast approaches its 250th birthday (to be celebrated next May), I’ve found it fascinating to look at how the school has changed -- and sometimes how its leaders have seemed to anticipate what lay ahead. Last month, the medical campus was visited by some... Read more
It’s only been a little over two weeks since the end of the 2014 Philadelphia Science Festival, but the inspiration, as well as love and knowledge of science that Penn Medicine faculty, staff, and students shared with members of the public, will last far into the next year.
The first annual Million Dollar Bike Ride is finally here. On Saturday, May 3, 2014, close to 500 riders and many other volunteers and family members will gather at Highline Park on Penn’s campus to raise funds for and awareness about rare diseases. Read more
Sleep -- elusive to some, mysterious to all -- is the topic of a special event at Franklin Institute’s Fels Planetarium on Wednesday, April 30, at 6:30 p.m. called Sleep: A Bedtime Story, part of the signature programs on the 2014 Philadelphia Science Festival schedule.
Head outdoors this weekend with Penn Medicine to kick off the fourth annual Philadelphia Science Festival.The weather for Saturday and Sunday is predicted to be 0% showers, with highs in the upper 60s and low 70s. Join Penn Medicine faculty, students, and staff at two of the city’s most spectacular...
Uncovering the genomic architecture of spider silk genes wasn’t top of mind for Benjamin Voight, PhD, when he first came to Penn a few years ago. But he and postdoctoral researcher Paul Babb are now deep into sequencing the whole genomes of two spider species: a Golden Silk Orb Weaver and Darwin's Bark Spider. Read more
PSF 2011 Carnival Dry icePenn Medicine will again play a starring role in the 4th annual Philadelphia Science Festival, a citywide collaboration showcasing science and technology every spring. Read more
In the mid-1990s, scientists for the first time were able to isolate and clone the BRCA1 and BRCA2 genes, mutations in which were thought to increase susceptibility to early onset breast and ovarian cancers. A new Perspective published last week in Science takes a look back at the last twenty... Read more
Working with many colleagues, a Penn team published in Nature the first application of 2PLM to directly quantify the physiological environment of blood stem cells, called haematopoietic stem cells, or HSCs. Read more