Penn Medicine News Blog Archive: Basic Science

Whole Genome Sequencing of Amish Families Reveals Complexity of Bipolar Disorder

By Karen Kreeger | September 16, 2014 | Comments Lonestar

Perelman School genetics professor Maja Bucan, PhD, told me of her deep appreciation for the work going on at the clinic: “From my first visit to the clinic [Clinic for Special Children], I knew I wanted to be part of their team as a collaborator.” Read more

Liver Regeneration Revealed: Hepatocytes Beget Hepatocytes

By Karen Kreeger | September 11, 2014 | Comments Prometheus Karl-Ludwig Poggemann Flickr

The regenerating liver is center stage in a modern story about how science similarly reinvents and readjusts itself, with a paper out in an early September issue of Cell Stem Cell from the lab of Ben Stanger. Read more

Double Trouble: How Parasitic Worms Weaken Antiviral Immunity

By Karen Kreeger | September 5, 2014 | Comments Artis CM cover warhol worms Sept 14

David Artis, PhD, professor of Microbiology and his team, including first author Lisa Osborne, PhD, demonstrated that mice already infected with parasitic helminths were worse at fighting viral infection. Read more

Making the Summer Count

By Karen Kreeger | August 15, 2014 | Comments SUIP_Poster Session_1

Every summer, the news is filled with profiles of summer student programs, and those that are aimed at increased participation by minority students in STEM are no exception. The Summer Undergraduate Internship Program at Penn Medicine is one such program. Read more

A Picture Really is Worth 1000 Words

By Karen Kreeger | August 1, 2014 | Comments Talamas winning image 2014

The winners of the Penn Medicine 2014 “Art in Science" can certainly make pretty pictures with fancy microscopes, but there is also a rich story of scientific inquiry behind each. Read more

Penn Medicine Remembers Victims of Malaysia Airlines Flight: A Loss to the HIV/AIDS Community

By Steve Graff | July 25, 2014 | Comments Ribbon

WHYY’s Radio Times’ show last Friday focused on much of the progress that’s been made in the world of HIV/AIDS research and care, but there was one terrible set back that had to be addressed. Earlier that morning, news broke that the Malaysia Airlines plane struck down over the Ukraine... Read more

The Force from Outside In: Cells Sense Surrounding Protein Stiffness for Insider Info

By Karen Kreeger | July 11, 2014 | Comments Assoian Bae blog post image final July 14

A new study is shedding light on how cells respond to surrounding “stiff” tissue that can influence cells to go rogue—and ultimately cause disease. A better understanding of that process could help advance the development of treatments for cancers and cardiovascular disease resistant to therapy. An article in Science Signaling... Read more

Exploring the Human Microbiome

By John Shea | July 2, 2014 | Comments PENN-Med_SPRING_2014_F3b_LR-1

Like many people, I have gone through life without paying much attention to my gut –- except, that is, for the times my stomach gave unmistakable indications that it was upset. Most of the time, what was happening inside said stomach remained unknown. On the whole, it was out of... Read more

What’s the Real Target for Attacking Pancreatic Tumors?

By Karen Kreeger | June 11, 2014 | Comments Pancreatic cancer ribbon

The lab of Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology, and colleagues, recently showed in a Cancer Cell study that some tumor components, particularly fibroblasts, constrain tumor growth. Read more

Dean Samuel Gurin Looks Ahead 50 Years

By John Shea | June 9, 2014 | Comments Gurin

As the Perelman School of Medicine fast approaches its 250th birthday (to be celebrated next May), I’ve found it fascinating to look at how the school has changed -- and sometimes how its leaders have seemed to anticipate what lay ahead. Last month, the medical campus was visited by some... Read more

2014 Philadelphia Science Festival Recap

By Karen Kreeger | May 20, 2014 | Comments

It’s only been a little over two weeks since the end of the 2014 Philadelphia Science Festival, but the inspiration, as well as love and knowledge of science that Penn Medicine faculty, staff, and students shared with members of the public, will last far into the next year.

Cycling for Rare Diseases

By Karen Kreeger | May 1, 2014 | Comments image from http://s3.amazonaws.com/hires.aviary.com/k/mr6i2hifk4wxt1dp/14061615/ea083ced-d221-4295-800d-0e745dcaf7ba.png

The first annual Million Dollar Bike Ride is finally here. On Saturday, May 3, 2014, close to 500 riders and many other volunteers and family members will gather at Highline Park on Penn’s campus to raise funds for and awareness about rare diseases. Read more

Sleep the Night Away with Penn Med Scientists at the Philadelphia Science Festival

By Karen Kreeger | April 29, 2014 | Comments PSF sleep blog post image

Sleep -- elusive to some, mysterious to all -- is the topic of a special event at Franklin Institute’s Fels Planetarium on Wednesday, April 30, at 6:30 p.m. called Sleep: A Bedtime Story, part of the signature programs on the 2014 Philadelphia Science Festival schedule.

An Outdoor Kickoff to the Philadelphia Science Festival

By Karen Kreeger | April 23, 2014 | Comments Sci Fest logo outside

Head outdoors this weekend with Penn Medicine to kick off the fourth annual Philadelphia Science Festival.The weather for Saturday and Sunday is predicted to be 0% showers, with highs in the upper 60s and low 70s. Join Penn Medicine faculty, students, and staff at two of the city’s most spectacular...

Using the Penn High Performance Computing Cluster to Unravel the Spider’s Web

By Karen Kreeger | April 15, 2014 | Comments Golden Silk Orb Weaver L Church Flickr Creative Commons

Uncovering the genomic architecture of spider silk genes wasn’t top of mind for Benjamin Voight, PhD, when he first came to Penn a few years ago. But he and postdoctoral researcher Paul Babb are now deep into sequencing the whole genomes of two spider species: a Golden Silk Orb Weaver and Darwin's Bark Spider. Read more

Penn Medicine at the 2014 Philadelphia Science Festival

By Karen Kreeger | April 4, 2014 | Comments PSF 2011 Carnival Dry ice

PSF 2011 Carnival Dry icePenn Medicine will again play a starring role in the 4th annual Philadelphia Science Festival, a citywide collaboration showcasing science and technology every spring. Read more

Twenty Years Later: How Breast Cancer Risk Genes are Changing Patient Care

By Katie Delach | April 1, 2014 | Comments image from http://hires.aviary.com/k/mr6i2hifk4wxt1dp/14040116/c3cea997-611f-46a2-b57c-3346cde4ae63.png

In the mid-1990s, scientists for the first time were able to isolate and clone the BRCA1 and BRCA2 genes, mutations in which were thought to increase susceptibility to early onset breast and ovarian cancers. A new Perspective published last week in Science takes a look back at the last twenty... Read more

Oxygen in our Bones

By Karen Kreeger | March 20, 2014 | Comments Vinogradov Nature image

Working with many colleagues, a Penn team published in Nature the first application of 2PLM to directly quantify the physiological environment of blood stem cells, called haematopoietic stem cells, or HSCs. Read more

Beyond the Ivory Tower: Penn’s Neuroscience Grad Students Reach Out During Brain Week, and Beyond

By Karen Kreeger | March 18, 2014 | Comments NGG KidsJudge 2013 Synpatic Land

Philadelphia is a cerebral city this spring. To start, every March, Brain Awareness Week brings together institutions worldwide to celebrate the brain. Read more

Transcription Factors Key to Using T Cells Against Cancer, Chronic Infection

By Karen Kreeger | March 6, 2014 | Comments Wherry BATF spiral blog post Mar 14

Business is brisk in the lab of John Wherry and his team from the Department of Microbiology and the Institute for Immunology for papers on killer and helper T cells. Two studies -- bound by their focus on transcription factors important in the immune response – have come out of the lab in the last few weeks. And, they both identify potential new targets for cancer immunotherapies. Read more

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