Les Dutton, Ph.D., will be awarded the 2013 John Scott Award next week. He will be honored with a medal, certificate, and $12,000 for his "work on the elementary processes of oxidation-reduction and the diverse biological events coupled to it." Dutton is the Eldridge Reeves Johnson Professor of Biochemistry and Biophysics, the director of the Johnson Foundation for Molecular Biophysics, a Fellow of the Royal Society, and former chair of the Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania. And an accomplished artist, but more on that later.
The work for which Dutton is cited for the Scott Award - "the elementary processes of oxidation-reduction and the diverse biological events coupled to it” – is an understatement.
“Bottom line – over the years, we have described how quantum mechanics is translated to basic biology via natural selection,” he says. “Every time we breathe, bringing oxygen into our bodies, we activate electron tunneling, which ultimately makes biochemical energy in the form of the molecule ATP. In a way, to put this fundamental knowledge into stark perspective, when humans die, we ultimately die of power failure.”
Patients with tumors that contain increased numbers of T lymphocytes generally survive longer than those with tumors without T-cell involvement, suggesting that T cells with potent antitumor function naturally exist in cancer and control tumor progression. With the exception of melanoma, it has been difficult to identify and isolate the tumor-reactive T cells from common cancers, however, the ability to do so could be used to fight a patient’s own cancer.
As our Nation takes a moment to salute and recognize the courageous men and women who served in our armed forces, the News Blog looks at Penn Medicine’s continuing support to one Philadelphia institution making a difference.
One such study is by a National Academies’ Committee on Science, Engineering, and Public Policy panel, who is updating the 2000 report Enhancing the Postdoctoral Experience for Scientists and Engineers. It will be interesting to see their recommendations on how well U.S. postdoc programs meet the needs of scientists and broader research activities, and how the postdoc landscape has changed over the last two decades. For example, a 1997 report from the Commission on Professionals in Science and Technology, Postdocs and Career Prospects: A Status Report, found that, overall, of those in postdocs in 1993, 13 percent were in tenure-track positions two years later, and for those in their second or third postdocs in the same year, 16 percent were in tenure-track positions by 1995.
Clearly, interest in career issues for postdocs is not new, but ways to expand the postdoc experience to ready for budding careers takes constant creativity and communication.
Prince Albert II of Monaco and Philadelphia Mayor Nutter Attend Ceremonial Signing Event at Penn Medicine
Penn Medicine hosted His Serene Highness Albert II, Prince of Monaco – whose mother, the late Princess Grace of Monaco was one of Philadelphia’s most beloved citizens – during an event on Saturday, October 26, to celebrate a new partnership between Penn Medicine and the Princess Grace Hospital in the Principality of Monaco. The new venture, which focuses on cardiovascular medicine and oncology, will allow patients in Monaco and Philadelphia to have access to some of the most innovative new treatments in these areas of medicine, and for students, faculty and staff from both institutions to learn from one another.
Philadelphia Mayor Michael Nutter was on hand for an event – featuring a ceremonial signing of the agreement and a plaque presentation – to formalize the partnership and commemorate His Serene Highness Albert II’s visit to Penn.
Prince Albert II of Monaco (top right) and Philadelphia Mayor Michael Nutter look on as Patrick Bini, Director of Princess Grace Hospital in Monaco (seated left), and J. Larry Jameson, MD, PhD, Dean of the Perelman School of Medicine and Executive Vice President of the University of Pennsylvania for the Health System, formally sign the agreement between Penn Medicine and the Princess Grace Hospital.
Monaco's Prince Albert II and Princess Charlene are greeted and presented with flowers upon their arrival at Penn Medicine's Perelman Center for Advanced Medicine.
Prince Albert II and Princess Charlene of Monaco talk with Stephen Hahn, MD, Chair of the Department of Radiation Oncology, to learn about the Roberts Proton Therapy Center's state-of-the-art cancer treatment facility.
Despite these rising figures, addiction to prescription opioids
is still widely misunderstood by the medical community and many of the factors
that play into a person’s path to abusing these drugs, due in part to the
illegal and taboo nature of the problem, are kept secret.
Doctors and other addiction specialists are desperate to
find clues into how the line between appropriate use and addiction becomes
blurred and now they are turning to social media messages to better understand the
roots of this dangerous epidemic.
Only 45 percent of Americans are registered organ donors. As a result, nearly 120,000 people in this country remain on a waiting list for a life-saving transplant. About 18 die each day due to a lack of available organs.
In an effort to increase donor registration, Penn Medicine partnered with HAP (The Hospital and Healthsystem Association of Pennsylvania) to help educate its employees about the importance of organ, eye, and tissue donation. It was part of a national campaign sponsored by the US Department of Health and Human Services. After an all-out effort that spread throughout its health system, Penn Medicine won recognition for having completed the widest variety of activities -- including information tables, special ‘lunch and learns,’ giveaways -– all to help raise awareness.
The face of autism
spectrum disorder (ASD) is often one of a child’s. But, as a slew of government
statistics, advocacy groups and high-profile newspaper articles have reminded
us as of late, kids with ASD eventually become adults. In fact, 45,000 to
50,000 kids with ASD reach adulthood every year—and age out of the system of care
that helped them through childhood, most likely provided by their school system.
“What are our next options?” Many parents and
caregivers may ask themselves when their child comes of age. The responsibility
often then shifts entirely to parents to find education or employment and
living arrangements. While most
typically-developing teenagers go on to college or work with relative ease, such
a transition to adulthood for young adults with ASD and their families can be
met with difficulties. Those issues include adjusting to daily life as an adult, education, psychiatric issues
associated with ASD, finding strengths, managing finances, work and social
Here at Penn, a
new and developing program aims to begin
to address that void in care. Led by Edward S. (“Ted”) Brodkin, MD, associate professor of Psychiatry, the Penn
Behavioral Health’s Adult Autism Spectrum Program’s
main goal is to help adolescents and adults with ASD and their families to
optimize their well-being, daily function and the growth of their talents,
skills and relationships.
“Most of today’s
resources are focused on children, but there’s a large wave of people with ASD
who are growing up to be adults who are going to need help—and there are very
few services available to them now,” says Dr. Brodkin.
Celebrating Life, Friendship and Personal Bonds at Pennsylvania Hospital’s 2013 Intensive Care Nursery Reunion
The careers of health care providers are some of the most stressful, yet most rewarding. Talk about running the full range a of emotions and experiences. Every day in hospitals around the world, nurses, physicians and therapists are on the front lines of health care, witnessing the intense highs of healing patients and sending them home, and the lows of caring for patients whose lives cannot be saved. At the top of those highs, health care workers sometimes have the opportunity to see patients beat seemingly insurmountable odds and go on to lead happy, productive lives. Plus, they have the satisfaction of knowing they played a important role in making that happen. Nowhere is this more apparent in an intensive care nursery.
Shown here in front of Pennsylvania Hospital’s original, historic Pine Building, are just some of the nearly 400 former patients and family members that attended the Hospital’s 2013 Intensive Care Nursery on October 5, 2013.
Last weekend nearly 400 people - 130 different families - came to Pennsylvania Hospital (PAH) for its bi-annual Intensive Care Nursery (ICN). Families were invited to come back to PAH to celebrate and reconnect with staff and other families with whom they forged deep bonds during their baby’s stay in the ICN. This year’s reunion theme was, “Never underestimate the size of miracles!" Held outdoors in the Hospital’s Elm Garden, it was a fall and Halloween-themed festival full of fun activities for children and adults alike: a bubble-blowing and painting table, pumpkin decorating, face painting, a photo booth and scrap-booking table, along with live music, free food (including barbeque and ice cream - always a kiddie fave), fundraising raffles, and silent auction to benefit the ICN.
The event was marked by a parade of super, SUV-like strollers toting adorable, multiple mini-passengers, lots of hugs, and laughter as staff reunited with their former patients. “It is so wonderful to be able to see how well our patients are doing and how big they’ve grown,” said Jeffrey S. Gerdes, MD, chair, Section of Newborn Pediatrics, “Although we routinely get photos and cards from families - especially around the holidays - showing us how well everyone is fairing, nothing beats seeing our former little patients in person.”
If a doctor applies a
band-aid with a smile, does a wound heal faster? Maybe not, but in today’s
changing health care landscape, health systems, physicians and insurance
providers alike are placing more emphasis on patient satisfaction, and recent
research suggests that it might not be safe to assume that a healthy patient is
a happy patient. According to an article in a
recent issue of AAOS Now, the journal of the American Academy of Orthopedic
Surgeons, historically, physicians have focused on technique and objective
outcomes as measures of ‘patient satisfaction,’ while patients have viewed their
satisfaction as a reflection of the physician-patient relationship.
Autumn Fiester, PhD, director of the Center for Clinical Ethics Mediation, leads a course for Penn faculty and staff on conflict-resolution
Now, in an effort to continue raising the bar on our quality
of care and help faculty to refine their leadership and development skills,
Penn Medicine’s Center for Clinical Ethics Mediation is providing courses aimed
at arming clinicians with the skills necessary to facilitate conflict
resolution at the bedside. In the health care setting, “conflict” can arise
when there are miscommunications over a patient’s medication regimen, differing
opinions regarding a course of treatment, cultural differences, etc. The
courses offered through the Center for Clinical Ethics Mediation take faculty
and staff out of the exam room and into the classroom where, through a series
of role-playing exercises, they are able to experience firsthand what it’s like
walking in their patients’ shoes.
This blog is written and produced by Penn Medicine's Department of Communications.
Views expressed are those of the author or other attributed individual and do not necessarily represent the official opinion of the related Department(s), University of Pennsylvania Health System (Penn Medicine), or the University of Pennsylvania, unless explicitly stated with the authority to do so.
Health information is provided for educational purposes and should not be used as a source of personal medical advice.